Interstate 80

Interstate 80, the United States’ second-longest Interstate highway, runs from San Francisco, CA, across the country to Teaneck, NJ, just outside New York City.

Wikipedia Entry

Western Terminus: San Francisco, CA (map)

Eastern Terminus: Teaneck, NJ (map)

Interstate 80 crosses the Delaware River, entering New Jersey from Pennsylvania (map) (Flickr set):

Interstate 80 enters New Jersey from Pennsylvania